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Does Minoxidil Stop Working Overtime?

Will Minoxidil Stop Working?

If your hair is falling out, you’ve likely scoured the internet for every possible treatment. Hair transplants are effective, but you might wince at the thought of a long recovery period and scarring. Your weekend brunch, Monday meeting, and patience don’t have time for that. Minoxidil is next on your list — a non-invasive, easy treatment, but you might wonder: does Minoxidil stop working after some time?

 

Picking a hair loss solution can be intimidating, especially if you’ve been disappointed before. But you don’t have to dive into Minoxidil feeling uncertain. The bottom line is you have questions:

  • How long does Minoxidil work for people with androgenetic alopecia?
  • When does Minoxidil stop working? 

 

Fortunately, we’ve got answers.  In this article, we’ll cover how Minoxidil regrows hair, why and when it might stop working.

 

Let’s start with your first question: Can Minoxidil stop working?  Download our guide to Minoxidil to learn everything you know about Minoxidil to regrow your hair.

 

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Will minoxidil stop working?

Minoxidil is the gift that keeps on giving — that is, for as long as you continue to use it. The hair loss drug’s effectiveness requires twice daily application every day. Say you notice some results after six months of using Minoxidil: you’ll notice a quick reversal of effects if you stop applying. 

 

One doctor at Donovan Hair Clinic says patients with genetic hair loss must use Minoxidil forever to maintain results. Otherwise, regrowth will halt and you’ll continue to lose your hair at the same rate as before or worse, even faster. Now, why does minoxidil stop working?

 

Assuming you’re a responder, your scalp needs Minoxidil to catalyze its active ingredient and regrow your hair. Once you stop using the drug, your scalp doesn’t hold onto it. It washes away along with your hair regrowth potential. But remember that it’s safe to keep using Minoxidil as long as you need it. 

 

Here, we’re talking about genetic hair loss cases. But Minoxidil doesn’t work the same for you if you have another hair loss cause. Consider telogen effluviumstress-related hair loss. Minoxidil might help you regrow hair initially, but eventually the stressor causing your hair loss will disappear. Your hair will resume its regular hair growth cycle and won’t need Minoxidil anymore. 

 

Let’s explore another scenario. You use Minoxidil religiously and never miss an application. You continue to use it for years, and suddenly, your hair regrowth stops and shedding resumes. 

 

What gives?

 

Dermatologist Jeff Donovan has an explanation. Assuming you have genetic hair loss, your genes may be multiplying as you age, quickening your shedding and balding. The genes work faster than Minoxidil in some cases. Donavan cites a study of baldness in 52,000 men that confirms the complicated nature of genes and the increase of hair loss genes as you age. 

 

Think of Minoxidil as exercise and hair follicles as your body. At 20, you have more muscle mass and energy to burn way more calories with exercise than you can at 50. Minoxidil works the same way — age factors (hair loss genes in this case) slow down progress.

 


 

HOW DOES MINOXIDIL WORK TO REGROW HAIR?

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Minoxidil is a vasodilator, and was first a blood pressure medication, not a hair loss solution. Researchers thought the drug dilated blood vessels, carving an easier path for oxygen and nutrients to travel across your body — including to your hair follicles. 

 

Now, extra nutrients certainly won’t hurt your hair. Your hair follicles crave omega fatty acids and protein to regulate hair growth, while Vitamins A, D, and B12 are linked to regrowth, too. 

 

Additionally, doctors once chalked the drug’s effects to its interference with the hair growth cycle, lengthening the anagen phase (growth) and shortening the telogen phase (resting). 

 

But neither nutrients nor hair growth cycle activity make up Minoxidil’s show-stopping regrowth mechanism. 

 

Daniel Alain’s research team of dermatologists and scientists recently discovered the novel SULT1A1 enzyme — the catalyst that awakens Minoxidil’s active component, Minoxidil sulfate. The right scalp enzyme activity metabolizes the drug to work its regrowth magic on your hair. 

 

But not everyone has SULT1A1 enzyme activity.

 


 DOES MINOXIDIL WORK FOR EVERYONE?

 

Unfortunately, Minoxidil won’t regrow everyone’s long-lost locks. Brand-name varieties like Rogaine® love to tout promising effectiveness claims, but they’re often based on specifically selected studies. The reality is that Minoxidil only works for 30-40% of people with genetic hair loss. 

 

Up until recently, nobody knew why. Sure, poor adherence to the application schedule might cause ineffectiveness for some users. Additionally, not waiting long enough before washing out the product could inhibit results. But those are easy fixes. What boggled dermatologists, doctors, and scientists was this: 

 

Why were thousands of people applying Minoxidil for months without seeing any results?

 

The common denominator in users who saw results was SULT1A1 scalp enzyme activity (Daniel Alain’s breakthrough discovery). If Minoxidil didn’t work for you after months of treatments, the lack of enzyme activity is why. 

 

But we ran into another dilemma: how do you know whether you have SULT1A1 enzyme activity in your scalp? Without this information, people might still take Minoxidil for months without knowing for certain if it would work.

How Can I Tell if Minoxidil Will Work for Me?

Daniel Alain’s Minoxidil Response Test (MRT) is the only way to determine whether Minoxidil will work for you. 

We back every single one of our hair loss solutions with science. Peer-reviewed studies, world-renowned scientists and dermatologists, and a CLIA-certified lab are at the forefront of our operation. And we wouldn’t have it any other way — the most luxurious and effective, patented hair solutions can’t thrive with anything less.

 

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How Does Minoxidil Testing Work?

All you have to do is order your MRT kit for men or women, register it, take a hair sample (six strands is all you need), and send it to our CLIA-certified lab. 

You’ll know whether it’s worth embarking on Minoxidil treatment within just one week! Remember, no other hair loss solution provider offers any remotely similar or effective test. Daniel Alain is the only place to purchase a Minoxidil Response Test. 

 


PICK THE BEST HAIR LOSS SOLUTION FOR YOU AT DANIEL ALAIN

Bottom line, does Minoxidil stop working for everyone? Not quite. Only for people who stop treatment, misapply the drug, or have genetic hair loss complications. Like every hair loss solution, Minoxidil has pros and cons. 

 

Your lifestyle and preferences dictate the best hair loss solution for your needs — but Minoxidil isn’t the only answer. Daniel Alain crafts the world’s finest wigs, made with the top 10% of premium European human hair. No waiting, no side effects — just luscious, silky-smooth hair every day. 


Have more questions? Luxurious hair is within reach. Talk to one of our hair stylists today about your options!

 

book a free consultation

Our stylists will help you find the right hair loss treatment for you

 

 


 Frequently Asked Questions

Does Minoxidil Lose its Efficacy?

Sometimes Minoxidil loses efficacy if hair loss genes in people with androgenetic alopecia multiply faster than Minoxidil’s hair regrowth mechanism. Additionally, Minoxidil will stop working as soon as you stop taking it or apply it incorrectly.

Do You Have to Use Minoxidil Forever?

Yes. Experts recommend you use Minoxidil for years to maintain regular hair regrowth and limit hair loss. However, the average Minoxidil timeline varies depending on your hair loss cause.

How Do You Apply Minoxidil?

Minoxidil has two forms: liquid and foam. Here’s how to apply the liquid solution:

  1. Part your hair into separate sections. 
  2. Apply the solution to affected areas of your scalp using the applicator (1ML). 
  3. Massage the solution into your scalp with your fingers. 
  4. Leave the solution on your scalp for at least four hours.

While side effects are rare, some people report allergic contact dermatitis with the liquid solution. You might try applying the minoxidil foam solution instead, and here’s how to do it:

  1. Wash your hands with cold water
  2. Part your hair into a few different sections, noting areas of hair thinning. 
  3. Take the cap off and dispense the foam onto your fingers. 
  4. Apply the foam to affected scalp areas, starting from the back. 
  5. Massage the solution into your scalp. 
  6. Leave the solution on your scalp for at least four hours.

How Often Do You Need to Use Minoxidil?

You must apply Minoxidil 1-2X daily (once in the morning and once at night) to see results. Remember to read the instructions label for more details.

Can You Develop a Tolerance to Minoxidil?

No. Experts assert that Minoxidil responders won't develop resistance to the drug over time. However, people with genetic hair loss might experience their condition worsen enough to mitigate Minoxidil’s effects, though. If you feel like Minoxidil is becoming less effective, other factors like seasonal hair shedding may be at play.

What Happens if Minoxidil Stops Working?

If Minoxidil stops working, you might notice your hair loss, thinning, or shedding resume as it did before you started treatment. However, discontinuing Minoxidil is the most common reason for it to stop working. 

Your next step is to consider Daniel Alain’s MRT to know for sure if it’s just a matter of time, as well as our Enzyme Booster. And if you’re still not happy with Minoxidil, there are always other hair loss solutions. You might consider another hair loss solution like INTACT or a premium human hair wig like our voluminous Style!

How Do You Know if Minoxidil is Not Working?

This is a tricky question because Minoxidil doesn’t often show results in the first six months of usage. Some users even report results delayed as much as nine months!

To make things more confusing, you might notice more hair shedding in the first few weeks of treatment — an effect that looks like the drug isn’t working. However, initial shedding is a good sign, indicating your scalp’s response to Minoxidil. Just consult a doctor if it lasts more than a few weeks. 


If you take Minoxidil for nine months or more and still don’t see results, chances are the drug isn’t working. But the best way to know for certain if Minoxidil will work is to take Daniel Alain’s MRT.

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How Long Does it Take for Minoxidil to Work?

Minoxidil takes between 6-9 months to work — a heavy con within Minoxidil’s pros and cons. However, you might notice some initial shedding within the first few weeks of treatment. Don’t worry; that just means your body is responding to the drug!

How Long Can You Use Minoxidil?

You can use Minoxidil for your entire life. The drug will continue to maintain hair regrowth as long as you use it. However, some responders dislike Minoxidil’s side effects that may develop over time, like dizziness, allergic contact dermatitis, and hypertrichosis (excessive body hair).

Is Minoxidil Harmful Long-term?

Minoxidil is safe for long-term use for most people, although most providers recommend against taking it if you’re under 18 years old. Additionally, some users report unsavory side effects like hypertrichosis, allergic contact dermatitis, and erectile dysfunction. Consult your doctor before taking Minoxidil.

Can Minoxidil Worsen Hair Loss?

Yes, Minoxidil causes hair loss (shedding) at the beginning of your treatment. But this is a normal side effect and indicates your body’s response to the drug. It should only last a few weeks, so consult a doctor if shedding persists for longer.

What Happens if You Miss a Day of Minoxidil?

If you miss a day of Minoxidil, it’s not a huge deal. Just take it as soon as you realize you’ve forgotten. However, if you’re close to your next scheduled dose, wait until then to apply it again. Remember to always follow the instructions on the package.

How Do You Increase Minoxidil Absorption?

The best way to boost Minoxidil absorption is to take Daniel Alain’s Booster — an enzyme supplement that increases your SULT1A1 enzyme levels by 7X! Additionally, healthy eating and exercise are always welcomed supplements to a healthy hair regimen.

 

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Brittany P.
Perfect kit

Perfect kit for someone starting out!

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Brittany P.
I had an amazing experience!

I had an amazing experience! Ashley was incredibly helpful! Love my new piece!

Hi Brittany! Thank you so much for your kind review. We truly appreciate you taking the time to share your experience. We’re delighted to hear that you had such a lovely visit and that our FOLLEA Expert, Ashley was able to provide with exceptional service. We hope you continue to love your new FOLLEA Style wig, and we’re always here if you need anything in the future!

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Samantha F.
Amazing Company

I recently lost my hair in a horse accident, but Daniel Alain was quick to help me out. I bought 3 toppers and I love all of them. They suit me extremely well, and I will forever be grateful. Thank you very much.

Hi Samantha! Thank you so much for sharing your experience. We're truly honored to be part of your hair journey and so happy to hear that you love your Follea by Daniel Alain hair toppers. Knowing they help you feel confident and comfortable means everything to us. Thank you for trusting Daniel Alain!

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Jessica A.
Ashley is wonderful!

Very impressed with the quality of service and quality of the hair piece!! Five stars!! Don’t waste time anywhere else.

Hello Jessica,

Thank you so much for sharing your experience with Ashley. We strive to be apart of every step of your journey, to ensure you have the best experience possible.

Love, The Daniel Alain Team

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Jenna D.
Unbelievable Experience

I was new to alternative hair and hit my rock bottom and realized I couldn’t put off a wig any longer. Ashley is absolutely incredible. She’s patient, knowledgeable, and so accommodating. She knew how vulnerable I felt and allowed me to take my time and get a piece I would be happiest with.

I am so grateful for this experience and I’m glad I found follea before being too traumatized elsewhere!

Truly, stop looking and buy the wig.

Dear Jenna,
Thank you so much for sharing your consultation experience with Ashley. It brings us so much joy to know she was able to help you find a piece that is best for you. We strive to help women feel comfortable and confident during there hair journey.

Xoxo, The Daniel Alain Team

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Bridget H.
Very helpful

We’ve been seeing a lot of hair loss in our clients due to Covid. Intact has helped to significantly reduce the shed! Our clients love it and so does the salon plumbing!

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Tara T.
Fear to FABULOUS!!

Ladies, if you’re asking yourself…”why is this so expensive in comparison to other options?”…don’t and take the plunge. You will know why INSTANTLY when you open it up! This purchase is for YOU to gain your confidence back, to feel pretty and to walk with pride so it’s worth it! We all spend so much on nothing, our kids, stupid things…We are worth investing in ourselves! I’m a first time buyer of a wig and I’m 51 yo. No current cancer or no chemo, just ruined my hair with extensions for many years. I experienced so much denial, fear, and much sadness but…Janet, what an angel…walked me through it, didn’t pressure me and was so incredibly patient with answering all my questions…she made me come to the realization how bad extensions are on your hair and if I’m going to try and see if I can regrow my hair, I need to take the extensions out, allow my head and follicles to breath naturally….all sounds like a good idea right? It was hard for me to realize this and knowing that I’d have to rely solely on a wig now at 51yo! But! As I mentioned above, it is worth it and I feel fabulous! It is so natural looking, it moves with you, it’s comfortable, and not crazy hot! You can style it however you want! I never write reviews but felt this was probably the most important one I could ever write in an effort to help someone else either like me who was afraid of needing a wig, or someone who is simply considering a new one from this company. And most of all, you are never alone through this journey. Janet is reachable and so helpful even after you receive it! I’m on the other side of the country from California and we went on this journey all via zoom and FaceTime! I’d you’re considering this, do it! They also graciously give you 7 days to decide, just keep it intact and no modifications and send it back for your money back or exchange! I didn’t mention that I purchased the “style” model and am extremely happy with it. I’ve only had it a week but wow, I’m me again and in minutes flat, I’m ready to go and look like I stepped out of the salon! If you’ve read this all, I wish you luck and congratulations on getting a new you…a gorgeous you, full of confidence!🤗

Dear Tara,

Your review closely touch all of our hearts and we can hope it does the same for others. We are pleased to know Janet was and is able to help you on your journey. Janet is a valuable asset here at Daniel Alain and to all the people she helps. Your kind words and review are the reason we strive to offer the absolute best quality human hair wigs and toppers. We are honored to be apart of your journey and re-gained self confidence.

Thank you for sharing your vulnerable and inspiring experience.

We would love to invite you to join our #FolleaFriend community on Instagram, Where you can share, learn and grow with other amazing Follea friends.

With Love, The Daniel Alain Team.

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Kelly B.
amazing customer service

I cant say enough good things about the customer service I received from Janet. I was nervous cause it was my first time ordering from you on top of that I was getting a custom color, not only was the color spot on, but Janet was sooo patient walking me thru the process
I never felt rushed or hurried to make a decision, honestly she was a dream to work with. Now I'm thinking about the next one I'm going to get;)

Dear Kelly,

Thank you so much for your kind and supportive words. We are glad to know Janet was able to be such a helpful and supportive part of your wig journey. Janet will always be glad to help with any and all questions and concerns you have.

We want to personally invite you to be apart of our @Follea Instagram community where you can Learn, Share, and Grow with other Follea Friends.

Thank you again!
With Love, The Daniel Alain Team

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Felicia J.C.
This is a great wig!

I absolutely love this wig and I wear it with tons of confidence! I purchased my Daniel Alain Follea Style wig on 12/24/20 and it still looks great! I wear wigs regularly due to hair loss and own other good quality wigs but once purchasing this one it has become my favorite wig and I have been wearing it about 5 days a week for over a year and a half. I wash and style it about once a week, use the best hair products available, style it with a T3 curling iron and even had it colored. I admit it is easier to style when on a stand but I have become pretty good at it and have not damaged it one bit, it still looks heathy and so soft. I wear it up, down, braided and even a pony tail, I do have to be a little creative when wearing it up but basically you can do with it whatever you would if it were your own natural hair.
I still love it so much and there is plenty of wear left but I thought it was time for a change and get a new one. When I went on line to look at styles again I realized I never reviewed it and that is why I am reviewing it now. Oh I almost forgot to mention how light and comfortable it is. I have worn it up to 18 hours, slept in it and even wear it on the beach without it feeling hot and sweaty, it really does not feel like you are wearing a wig. If you are on the fence about purchasing a Daniel Alain wig I can tell you it is a very good quality wig and you won't be sorry. Here are a few pics of me styling it and wearing it in different styles, the one of me in blue was last week and about 2 months after coloring it.

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Stacy C.
Simply the Best

I get so many compliments on this wig. The Cappuccino color is so beautiful! I feel so confident when I wear her. I’ve worn so many of the years and I finally feel like I’ve found the one.

Dear Stacy,

We couldn't be happier to hear how beautiful and confident you feel in your new Follea! It warms our hearts to be apart, and a positive affect during your hair loss journey.

We invite you to join our @Follea community on Instagram, to learn best practices for your new Follea. Thank you so much!

XOXO, The Daniel Alain Team

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Ruth T.

Beautiful wigs and the best customer service!!

Dear, Ruth
Thank you so much for your kind words! We take comfort in knowing you were pleased with the help and assistance you received during this process.
Xoxo, The Daniel Alain Team

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M. T.W.
Easy Beauty!

My Follea Style (6-11) is in all honesty the most comfortable wig I've ever worn - and I hate anything on my head! This wig just... goes where it's supposed to, no pulling it this way or that, no realizing your doggone wig is crooked.. AFTER you walk in to work. This success is in no small part to the Fit Kit I was sent to make sure of my size. 😊

Also, to say the hair is beautiful gives beauty a bad name. The hair is stunning. (I wear color Latte.) My consultant, Ashley, virtually took my hand to guide me through the process of buying my wig. Her help was and still is invaluable.

My hairdresser is very comfortable styling wigs. She created just the right "style" for my Style. That said, even straight from the box, Follea rocks!

Reading your Follea experience warms our hearts, our goal and mission is to help women all over the world feel beautiful, confident and like their best self. Ashley is an amazing and knowlegable guide, that will continue to be with you on your hair journey!

We invite you to join our @Follea community on Instagram, to learn best practices for your new Follea.

Thank you very much!

Love,

Daniel Alain Team

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Kimberlee B.
Wig #6

The ready to wear wig I received from Daniel Alain is beautiful. The packaging was so respectful of the wig. So impressed. I called with questions before purchasing and the staff was very kind and respectful as Loosing my hair was so unexpected and stressful. Thank you for wonderful customer service and a beautiful wig. So many compliments on how it makes me look. Thank you.

We are honored and so glad to hear you had a pleasant experience! Thank you or trusting us to help you during your hair-loss journey.

Follea René

Ive had my follea Rene, 12 inch in the color Vienna, for almost a week and I love it more every day. I feel like a new woman, so confident and beautiful again. This wig has given me a bounce in my step again. It’s so soft, silky, doesn’t matte like my other wigs and feels like it is coming right out of my own head. Cynthia at follea did a virtual visit explaining everything, answering all my questions and sent me samples of wig caps and color swatches to try on. The process was stress free and exciting. Will definitely purchase another follea for sure.

Hi Nikki,

Thank you so much for taking the time out of your day to write this review for us. We are so glad to know that you are loving our René wig and more importantly, feeling like confident and beautiful again! Please tag us #danielalain in any photos we'd love to share your amazing look on our website and/or social media platforms.

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Mercedes
Style 10 Inch Color 5005 Macchiato (comes with a soft rooting)

This is my first wig but not my first attempt with alternative hair. Its been a journey and one I knew I wanted to take with Follea. I was not wrong. The hair is silky soft and beautifully shiny. The staff is great and wonderful to work with. Their online consultation process is just what I needed. I received sample caps to try on to determine which size is the right size for me. I received color swatches as well to make the color selection process was a breeze. It does make a difference to see to the colors in person, dont be afraid to ask for color swatches. To see them against the light or while your home is worth it. All this happened after the online consultation, which was simple and fun. The rep provided samples of everything, explained the differences with each one. This helped me make a decision on what was right for me. Getting the samples of the wig caps and color swatches was a fun part of the experience but it also made me feel good about my decisions. I often worry about getting the wrong size and color. Once I was set ( and yes I changed my mind a bit) we went forward with the order. After I received my wig and cut the lace, the team was still there to help me with any questions I had.

Overall a great online purchasing experience. Once I received my Follea, I instantly knew this was it for me. I loved it and I was confident to wear it out.

Feeling Myself and Happy with a beautiful Follea Style, 10", Irish Cream

There are no words to fully express how grateful I am for finding Follea and meeting Janet. Her kindness combined with a professional, yet so gentle, advice helped me to find my beautiful natural looking European hair. Janet patiently showed me different styles and sizes (my head is so small!). She has never pushed me to anything. Only offered support and help on the way to my decision, and eventually ordered (incredibly urgently) the right size. I wish all patients to meet someone like Janet on their way! Before I found Follea, I faced a few horrible pushy people who wanted to make money of my sensitive, fragile situation of suddenly losing hair.
Today, I can face the Universe with a smile, again. I am back to work and normal life, interacting with people, attending important business meetings. Letting my health recover in calm confident state.
Thank You to Follea and Janet. May the Blessing and Kindness come back to You Multiplied Million Times.
I am already thinking of ordering a second Follea Style (bit longer this time). Every girl needs a special occasion HAIR! I have found mine.

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erin g.
Looooove me some FOLLEA!!!

Girl I love my new wig!!!!!! I feel like Beyoncé wearing it, you can’t even tell that it’s a wig! My confidence is an all new high and I feel fierce. Thanks to Janet for making my hair dreams come true. Xoxoxo

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Heather L.
Follea's Petite

Recently, I bought the Petite in Chai Latte blonde with a natural-looking darker root and customized my piece by adding a few wispy bangs. If you are like me and try to stretch the length of time between washes to prevent an itchy scalp and breakage, this little priceless gem is a quick four clips away from a good hair day.

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Diane B.
Great Customer Services

Great customer services! Received in a timely manner. Very happy with my topper, especially after I trimmed bangs and length to fix my own hair.

Hello Diane,

Thank you so much for taking the time out of your day to write this review for us. We are very happy to receive your feedback. Please tag us #danielalain in any photos we'd love to share your amazing look on our website and/or social media platforms.
Feel free to contact us at 1.949.706.9880 or reviews@danielalain.com.

XO