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Why Doesn't Minoxidil Work for Everyone?

Why Doesn't Minoxidil Work for Everyone?

 

Minoxidil is an FDA-approved hair loss solution that regrows lost hair. Popular brand name versions like Rogaine®  tout impressive effectiveness, but a closer look reveals a harsh truth: Minoxidil doesn’t always work. 

 

But why doesn’t Minoxidil work for everyone?

 

Daniel Alain embarked to find out in his state-of-the-art lab, employing only the best dermatologists and scientists to explore Minoxidil’s effectiveness. Along with 100% European human hair wigs, Daniel Alain offers innovative products to make Minoxidil work for you. 

 

But the question remains: why isn’t Minoxidil working for me in the first place? We know you don’t have months to squander waiting for results — family events, work meetings, and that much-needed vacation await! 

 

Keep reading. We’ll walk through how Minoxidil regrows hair, why it doesn’t work for everyone, and how you can optimize the drug if you aren’t a responder. 

 

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WHY MINOXIDIL MAY NOT WORK FOR YOU

Most hair loss solutions can’t regrow your hair. Your average cream or product might contain emollients or other nutrients to promote hair health. Solutions like INTACT 5 focus on retaining existing hair.

 

Minoxidil was a game changer in the hair loss industry because it showed promising results at regrowing lost hair. 

 

And it didn’t need long recovery times for scarring, like hair transplants, or excessive price tags like PRP (Platelet-Rich Plasma)

 

Minoxidil shortens your hair growth cycle’s telogen phase, speeding up its course to the coveted growth phase and extending it (anagen). Originally formulated as a vasodilator, Minoxidil stimulates hair follicle microcirculation and enables better oxygen flow and nutrients. Finally, the drug has been proven to increase hair diameter and length. 

 

But something was missing in countless studies. All the above reasoning didn’t explain why Minoxidil only worked for 30-40% of people who tried it.

 

So, why doesn’t Minoxidil work for everyone? 

 

Your hair loss cause could offer some clarity. Minoxidil is an FDA-approved drug for androgenetic alopecia — genetic hair loss. If you have chemotherapy-related hair loss, telogen effluvium, seasonal hair shedding, or hair loss resulting from medication, Minoxidil might not be as effective. 

 

If you’re undergoing chemo, the hair loss won’t stop until the treatment does. Likewise, telogen effluvium won’t subside until you remove the stressor — nutritional elements or life stress, for example. And seasonal hair shedding? That’s just a matter of time. 

 

But if you do have genetic hair loss and still don’t see results? 

 

It’s a common story. Unfortunately, some men and women with androgenetic alopecia still wonder: why isn't Minoxidil working for me?

 

Nobody knew until Daniel Alain investigated. 

 

Our team of professionals discovered a key factor in Minoxidil’s effectiveness: SULT1A1 enzyme activity. 

 

If your scalp naturally produced this enzyme environment, Minoxidil would work for you within a few months. Congratulations — you’re a responder. If it didn’t? You could go years applying Minoxidil religiously to no avail. 

 

See, SULT1A1 enzyme activity is the only way your scalp can activate Minoxidil’s active component: Minoxidil sulfate. 

 

But how do you know if you have it? 

 


 

HOW TO TELL IF MINOXIDIL WILL WORK FOR YOU

Scientists around the world accepted Minoxidil’s long waiting period for results. Many hair professionals agree you wouldn’t see regrowth for at least four months, but usually between 6-9.  

 

Imagine waiting that long only to see absolutely zero results. Naturally, you’re going to wrack your brain to answer the frustrating question: Why isn't minoxidil working? 

 

Maybe you’ve already been there. We know hundreds of men and women that have given up on Minoxidil after months of minimal results. 

 

Hair loss is so paralyzing when you’re uncertain about your specific cause and the right treatment. Awareness doesn’t solve the shame and discomfort, but it does soothe some anxiety. 

 

That’s what we set out to achieve when we created the Minoxidil Response Test (MRT).

 

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Daniel Alain’s MRT is the only sure way to know whether you’ll respond to Minoxidil. And it takes between 1-2 weeks to give you answers. Forget taking months-long leaps of faith in your hair loss journey. Our test gives you the certainty you need to embark on a hair loss solution — Minoxidil or other — with confidence. 

How Minoxidil Testing Works

Let us bring the same professionalism, accuracy, and certainty we have in our CLIA-certified lab to your home. We’ve made testing for Minoxidil as non-invasive and seamless as possible with the MRT. 

 

The whole process takes a maximum of two weeks, from start to finish. 

 

Here’s how:

  1. Order your MRT kit on Daniel Alain's website.  Each kit, whether for men or women, costs $139.00.
  2. Register your kit.
  3. Pluck six hair strands off your head.
  4. Send Daniel Alain your hair strands for testing.  We'll test them for SULT1A1 enzyme activity in our CLIA-certified lab, which holds state and federal certifications.  Additionally, we submit to regular inspections.
  5. Wait for result.  We'll let you know whether Minoxidil will work for you within 7 - 14 days!  Beat testing out Minoxidil for months, right?

 

Worried about confidentiality? We’re HIPAA-compliant and use bank-grade encryption to protect customer data. So rest easy, knowing your hair strands and health information are secure, safe, and discreet with Daniel Alain. 

 

But what if you test negative for the SULT1A1 enzyme activity? 

 

You have two options. Perhaps you can explore other hair loss solutions like premium, human hair wigs, or hair retention through INTACT 5

 

If you're intent on regrowing lost hair, you could also try hair transplants or PRP, but those are costly procedures that could leave scarring. 

 

Minoxidil is always an option for you if you allow Daniel Alain to help! But it’s not the only hair loss solution.

 


 

TAKE CONTROL OF YOUR HAIR LOSS WITH DANIEL ALAIN

So, why does Minoxidil not work for everyone? It could be a matter of an incompatible hair loss cause, or a lack of SULT1A1 enzyme activity. 

 

But you can secure your odds with Daniel Alain’s MRT.

 

Of course, you’ll still need to wait months to see results — a downer if you’re dreaming of va-va-voom volume for next weekend’s soirée. 

 

If Minoxidil doesn’t meet your needs, our 100% premium European human hair wigs will. We source the top 10% of hair in the world from Eastern Europe and place it in the hands of skilled wig artisans to create our Follea collection


Whatever your hair loss goals are, get in touch to see how we can help!

 

book a free consultation

Our stylists will help you find the right hair loss treatment for you

 

 


 

Frequently Asked Questions

How Much Does Minoxidil Testing Cost?

Daniel Alain’s Minoxidil Response Test (MRT) costs $139.00 for both men and women. You can also make installments of $35.00 per month for four months. 

How Do I Apply Minoxidil?

Always follow application instructions closely when applying Minoxidil. You’ll find them on the box or inside a pamphlet. Remember, Minoxidil has both a liquid and foam form. We’ll walk through instructions for each. 

 

Liquid solution application instructions: 

  1. Separate your hair into distinct sections. 
  2. Fill the applicator to the instructed amount (1ML). 
  3. Drop the liquid with the applicator onto exposed areas of your scalp. 
  4. Rub the solution into your scalp with your fingers. 
  5. Let rest on your scalp for a minimum of four hours. 

The liquid solution is just as effective as the foam solution. However, people who use the liquid solution report more instances of allergic contact dermatitis than with the foam solution. 

 

Foam solution application instructions: 

  1. Look for specific thinning areas of your hair. 
  2. Separate your hair into sections. 
  3. Dispense the required amount of foam onto your fingers. 
  4. Beginning with thinning areas at the back of your head, apply the foam solution to your scalp. 
  5. Massage the solution with your fingers, 
  6. Let rest on your scalp for at least four hours. 

How Long Does Minoxidil Take to Work?

Minoxidil can take four months to work for some users, but most experts agree a 6-9 month timeline is more common. 

How Do You Know if Minoxidil is Working?

The first sign of Minoxidil’s effectiveness is shedding. At the start of treatment, Minoxidil speeds up the telogen phase (resting). Now, this takes your hair growth cycle closer to the anagen (growth phase). 

However, you’ll end up passing through the exogen phase (shedding) first. If you notice shedding continues for longer than a few weeks, consult a doctor. 

Is There a Way to Make Minoxidil More Effective?

Daniel Alain’s Enzyme Supplement is a sure way to improve Minoxidil’s effectiveness. If you don’t have SULT1A1 enzyme scalp activity, the supplement boosts the enzyme to help activate Minoxidil. 

Does Minoxidil Thicken Hair?

Yes, Minoxidil is known to increase hair diameter and regrow lost hair, which both increase density and make your hair look thicker. On top of that, it mitigates thinning along a widening hair part, and fills in receding hairlines. 

Can Minoxidil Worsen Hair Loss?

Yes, Minoxidil can instigate hair shedding at the start of treatment. However, that’s a sign the drug is working. Minoxidil accelerates the hair growth cycle, which passes through a short stint of hair shedding. Just consult a doctor if the shedding doesn’t subside within a few weeks. 

What Happens if I Use Too Much Minoxidil?

You should always follow application instructions to avoid under or overusing the drug. While extra applications aren’t known to cause any serious effects, higher-potency versions of Minoxidil, namely the 5% over the 2% solution, sometimes cause hypertrichosis (excessive hair growth on the body). 

What is the Alternative to Minoxidil?

You have plenty of alternatives to Minoxidil. While few can regrow hair, most offer the coverage you need to feel confident about your hair again. 

Daniel Alain’s premium, 100% European human hair wigs offer unparalleled bounce, sleekness, and security even through your highest-activity days. 

And if you want to stop your hair shedding under the wig? INTACT 5 can help with its root-securing technology and hydrating coconut fatty acids. 

Do You Need to Use Minoxidil Forever?

Unfortunately, doctors link Minoxidil effectiveness to the length of time you use it. That means ceasing application might result in hair shed returning. Of course, you could try a human hair wig or a topper if you’re tired of applying Minoxidil. 

Our wigs are hand-tied and made with premium European human hair — two ingredients to an undetectable, voluminous look. 

Can You Develop a Tolerance to Minoxidil?

Technically, you can’t develop a tolerance to Minoxidil. But if you notice effectiveness dwindling, your genetic hair loss could develop faster than Minoxidil’s effectiveness. 

When Should I Stop Using Minoxidil?

You should only stop using Minoxidil if you feel comfortable enough with your hair loss situation to accept shedding. Or, you might stop applying Minoxidil if you find another solution that works better for you. 

How Often Do You Need to Use Minoxidil?

You should apply Minoxidil twice daily to see best results. If you miss an application, don’t worry. Either apply Minoxidil as soon as you remember, or continue your regular schedule if it’s close to your next dosage time. 

Does Minoxidil Only Work Where Applied?

Yes and no. While instructions guide users to apply Minoxidil on the scalp, some people notice hair growth in other areas. Hypertrichosis is sometimes a side effect, resulting in body hair on the back, face, stomach, arms, and more. 

How Often Should I Wash My Hair While Using Minoxidil?

You should wash your hair every couple of days, or as often as recommended by a hair stylist or doctor. Minoxidil shouldn’t change your hair hygiene routine. However, you shouldn’t wash your hair until after four hours since your last Minoxidil application. 


If you take Minoxidil for nine months or more and still don’t see results, chances are the drug isn’t working. But the best way to know for certain if Minoxidil will work is to take Daniel Alain’s MRT.

 

 

 

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Samantha F.
Amazing Company

I recently lost my hair in a horse accident, but Daniel Alain was quick to help me out. I bought 3 toppers and I love all of them. They suit me extremely well, and I will forever be grateful. Thank you very much.

Hi Samantha! Thank you so much for sharing your experience. We're truly honored to be part of your hair journey and so happy to hear that you love your Follea by Daniel Alain hair toppers. Knowing they help you feel confident and comfortable means everything to us. Thank you for trusting Daniel Alain!

J
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Jessica A.
Ashley is wonderful!

Very impressed with the quality of service and quality of the hair piece!! Five stars!! Don’t waste time anywhere else.

Hello Jessica,

Thank you so much for sharing your experience with Ashley. We strive to be apart of every step of your journey, to ensure you have the best experience possible.

Love, The Daniel Alain Team

J
Daniel Alain
Jenna D.
Unbelievable Experience

I was new to alternative hair and hit my rock bottom and realized I couldn’t put off a wig any longer. Ashley is absolutely incredible. She’s patient, knowledgeable, and so accommodating. She knew how vulnerable I felt and allowed me to take my time and get a piece I would be happiest with.

I am so grateful for this experience and I’m glad I found follea before being too traumatized elsewhere!

Truly, stop looking and buy the wig.

Dear Jenna,
Thank you so much for sharing your consultation experience with Ashley. It brings us so much joy to know she was able to help you find a piece that is best for you. We strive to help women feel comfortable and confident during there hair journey.

Xoxo, The Daniel Alain Team

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Daniel Alain
Bridget H.
Very helpful

We’ve been seeing a lot of hair loss in our clients due to Covid. Intact has helped to significantly reduce the shed! Our clients love it and so does the salon plumbing!

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Tara T.
Fear to FABULOUS!!

Ladies, if you’re asking yourself…”why is this so expensive in comparison to other options?”…don’t and take the plunge. You will know why INSTANTLY when you open it up! This purchase is for YOU to gain your confidence back, to feel pretty and to walk with pride so it’s worth it! We all spend so much on nothing, our kids, stupid things…We are worth investing in ourselves! I’m a first time buyer of a wig and I’m 51 yo. No current cancer or no chemo, just ruined my hair with extensions for many years. I experienced so much denial, fear, and much sadness but…Janet, what an angel…walked me through it, didn’t pressure me and was so incredibly patient with answering all my questions…she made me come to the realization how bad extensions are on your hair and if I’m going to try and see if I can regrow my hair, I need to take the extensions out, allow my head and follicles to breath naturally….all sounds like a good idea right? It was hard for me to realize this and knowing that I’d have to rely solely on a wig now at 51yo! But! As I mentioned above, it is worth it and I feel fabulous! It is so natural looking, it moves with you, it’s comfortable, and not crazy hot! You can style it however you want! I never write reviews but felt this was probably the most important one I could ever write in an effort to help someone else either like me who was afraid of needing a wig, or someone who is simply considering a new one from this company. And most of all, you are never alone through this journey. Janet is reachable and so helpful even after you receive it! I’m on the other side of the country from California and we went on this journey all via zoom and FaceTime! I’d you’re considering this, do it! They also graciously give you 7 days to decide, just keep it intact and no modifications and send it back for your money back or exchange! I didn’t mention that I purchased the “style” model and am extremely happy with it. I’ve only had it a week but wow, I’m me again and in minutes flat, I’m ready to go and look like I stepped out of the salon! If you’ve read this all, I wish you luck and congratulations on getting a new you…a gorgeous you, full of confidence!🤗

Dear Tara,

Your review closely touch all of our hearts and we can hope it does the same for others. We are pleased to know Janet was and is able to help you on your journey. Janet is a valuable asset here at Daniel Alain and to all the people she helps. Your kind words and review are the reason we strive to offer the absolute best quality human hair wigs and toppers. We are honored to be apart of your journey and re-gained self confidence.

Thank you for sharing your vulnerable and inspiring experience.

We would love to invite you to join our #FolleaFriend community on Instagram, Where you can share, learn and grow with other amazing Follea friends.

With Love, The Daniel Alain Team.

K
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Kelly B.
amazing customer service

I cant say enough good things about the customer service I received from Janet. I was nervous cause it was my first time ordering from you on top of that I was getting a custom color, not only was the color spot on, but Janet was sooo patient walking me thru the process
I never felt rushed or hurried to make a decision, honestly she was a dream to work with. Now I'm thinking about the next one I'm going to get;)

Dear Kelly,

Thank you so much for your kind and supportive words. We are glad to know Janet was able to be such a helpful and supportive part of your wig journey. Janet will always be glad to help with any and all questions and concerns you have.

We want to personally invite you to be apart of our @Follea Instagram community where you can Learn, Share, and Grow with other Follea Friends.

Thank you again!
With Love, The Daniel Alain Team

F
Daniel Alain
Felicia J.C.
This is a great wig!

I absolutely love this wig and I wear it with tons of confidence! I purchased my Daniel Alain Follea Style wig on 12/24/20 and it still looks great! I wear wigs regularly due to hair loss and own other good quality wigs but once purchasing this one it has become my favorite wig and I have been wearing it about 5 days a week for over a year and a half. I wash and style it about once a week, use the best hair products available, style it with a T3 curling iron and even had it colored. I admit it is easier to style when on a stand but I have become pretty good at it and have not damaged it one bit, it still looks heathy and so soft. I wear it up, down, braided and even a pony tail, I do have to be a little creative when wearing it up but basically you can do with it whatever you would if it were your own natural hair.
I still love it so much and there is plenty of wear left but I thought it was time for a change and get a new one. When I went on line to look at styles again I realized I never reviewed it and that is why I am reviewing it now. Oh I almost forgot to mention how light and comfortable it is. I have worn it up to 18 hours, slept in it and even wear it on the beach without it feeling hot and sweaty, it really does not feel like you are wearing a wig. If you are on the fence about purchasing a Daniel Alain wig I can tell you it is a very good quality wig and you won't be sorry. Here are a few pics of me styling it and wearing it in different styles, the one of me in blue was last week and about 2 months after coloring it.

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Stacy C.
Simply the Best

I get so many compliments on this wig. The Cappuccino color is so beautiful! I feel so confident when I wear her. I’ve worn so many of the years and I finally feel like I’ve found the one.

Dear Stacy,

We couldn't be happier to hear how beautiful and confident you feel in your new Follea! It warms our hearts to be apart, and a positive affect during your hair loss journey.

We invite you to join our @Follea community on Instagram, to learn best practices for your new Follea. Thank you so much!

XOXO, The Daniel Alain Team

R
Daniel Alain
Ruth T.

Beautiful wigs and the best customer service!!

Dear, Ruth
Thank you so much for your kind words! We take comfort in knowing you were pleased with the help and assistance you received during this process.
Xoxo, The Daniel Alain Team

M
Daniel Alain
M. T.W.
Easy Beauty!

My Follea Style (6-11) is in all honesty the most comfortable wig I've ever worn - and I hate anything on my head! This wig just... goes where it's supposed to, no pulling it this way or that, no realizing your doggone wig is crooked.. AFTER you walk in to work. This success is in no small part to the Fit Kit I was sent to make sure of my size. 😊

Also, to say the hair is beautiful gives beauty a bad name. The hair is stunning. (I wear color Latte.) My consultant, Ashley, virtually took my hand to guide me through the process of buying my wig. Her help was and still is invaluable.

My hairdresser is very comfortable styling wigs. She created just the right "style" for my Style. That said, even straight from the box, Follea rocks!

Reading your Follea experience warms our hearts, our goal and mission is to help women all over the world feel beautiful, confident and like their best self. Ashley is an amazing and knowlegable guide, that will continue to be with you on your hair journey!

We invite you to join our @Follea community on Instagram, to learn best practices for your new Follea.

Thank you very much!

Love,

Daniel Alain Team

K
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Kimberlee B.
Wig #6

The ready to wear wig I received from Daniel Alain is beautiful. The packaging was so respectful of the wig. So impressed. I called with questions before purchasing and the staff was very kind and respectful as Loosing my hair was so unexpected and stressful. Thank you for wonderful customer service and a beautiful wig. So many compliments on how it makes me look. Thank you.

We are honored and so glad to hear you had a pleasant experience! Thank you or trusting us to help you during your hair-loss journey.

Follea René

Ive had my follea Rene, 12 inch in the color Vienna, for almost a week and I love it more every day. I feel like a new woman, so confident and beautiful again. This wig has given me a bounce in my step again. It’s so soft, silky, doesn’t matte like my other wigs and feels like it is coming right out of my own head. Cynthia at follea did a virtual visit explaining everything, answering all my questions and sent me samples of wig caps and color swatches to try on. The process was stress free and exciting. Will definitely purchase another follea for sure.

Hi Nikki,

Thank you so much for taking the time out of your day to write this review for us. We are so glad to know that you are loving our René wig and more importantly, feeling like confident and beautiful again! Please tag us #danielalain in any photos we'd love to share your amazing look on our website and/or social media platforms.

XO

M
Daniel Alain
Mercedes
Style 10 Inch Color 5005 Macchiato (comes with a soft rooting)

This is my first wig but not my first attempt with alternative hair. Its been a journey and one I knew I wanted to take with Follea. I was not wrong. The hair is silky soft and beautifully shiny. The staff is great and wonderful to work with. Their online consultation process is just what I needed. I received sample caps to try on to determine which size is the right size for me. I received color swatches as well to make the color selection process was a breeze. It does make a difference to see to the colors in person, dont be afraid to ask for color swatches. To see them against the light or while your home is worth it. All this happened after the online consultation, which was simple and fun. The rep provided samples of everything, explained the differences with each one. This helped me make a decision on what was right for me. Getting the samples of the wig caps and color swatches was a fun part of the experience but it also made me feel good about my decisions. I often worry about getting the wrong size and color. Once I was set ( and yes I changed my mind a bit) we went forward with the order. After I received my wig and cut the lace, the team was still there to help me with any questions I had.

Overall a great online purchasing experience. Once I received my Follea, I instantly knew this was it for me. I loved it and I was confident to wear it out.

Feeling Myself and Happy with a beautiful Follea Style, 10", Irish Cream

There are no words to fully express how grateful I am for finding Follea and meeting Janet. Her kindness combined with a professional, yet so gentle, advice helped me to find my beautiful natural looking European hair. Janet patiently showed me different styles and sizes (my head is so small!). She has never pushed me to anything. Only offered support and help on the way to my decision, and eventually ordered (incredibly urgently) the right size. I wish all patients to meet someone like Janet on their way! Before I found Follea, I faced a few horrible pushy people who wanted to make money of my sensitive, fragile situation of suddenly losing hair.
Today, I can face the Universe with a smile, again. I am back to work and normal life, interacting with people, attending important business meetings. Letting my health recover in calm confident state.
Thank You to Follea and Janet. May the Blessing and Kindness come back to You Multiplied Million Times.
I am already thinking of ordering a second Follea Style (bit longer this time). Every girl needs a special occasion HAIR! I have found mine.

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Daniel Alain
erin g.
Looooove me some FOLLEA!!!

Girl I love my new wig!!!!!! I feel like Beyoncé wearing it, you can’t even tell that it’s a wig! My confidence is an all new high and I feel fierce. Thanks to Janet for making my hair dreams come true. Xoxoxo

H
Daniel Alain
Heather L.
Follea's Petite

Recently, I bought the Petite in Chai Latte blonde with a natural-looking darker root and customized my piece by adding a few wispy bangs. If you are like me and try to stretch the length of time between washes to prevent an itchy scalp and breakage, this little priceless gem is a quick four clips away from a good hair day.

D
Daniel Alain
Diane B.
Great Customer Services

Great customer services! Received in a timely manner. Very happy with my topper, especially after I trimmed bangs and length to fix my own hair.

Hello Diane,

Thank you so much for taking the time out of your day to write this review for us. We are very happy to receive your feedback. Please tag us #danielalain in any photos we'd love to share your amazing look on our website and/or social media platforms.
Feel free to contact us at 1.949.706.9880 or reviews@danielalain.com.

XO